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Cristina Pujades

DCEXS-Universitat Pompeu Fabra
Dr Aiguader 88
Barcelona, Barcelona 8003


Taxa Studied: Vertebrate Animals
Techniques Employed: Degenerate PCR, Quantitative PCR (qPCR), In Situ Hybridization, Antibody Staining, Sectioning for Histology, Epifluoresence Microscopy, Confocal Microscopy, Time-Lapse Microscopy, Transgenesis, Mutagenesis, RNA interference(RNAi), Morpholinos
Research Description: The long-term goal of our group is to understand the molecular and cellular mechanisms governing the patterning along the anterior-posterior (AP) axis of the hindbrain, the posterior part of the brain. AP patterning of the hindbrain involves a segmentation process, which leads to the formation of morphological bulges called rhombomeres. This segmentation process sets up the stereotyped pattern of neuronal specification in the brainstem. Our interest is focused on what mechanisms underlie rhombomere boundary formation, and what are the early events that dictate the overall segmentation of the hindbrain. Another aspect of our work concerns the study of the establishment of the neurosensory domain of the inner ear and the role of proneural genes in cell fate determination within this progenitor territory. We use zebrafish as a model system, adn we did some EvoDevo work using lamprey embryos.
Lab Web Page: http://www.upf.edu/devbiol/projectes/cns.html
Willing to Host Undergraduates: YES
Actively Seeking Undergraduates: YES
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