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lab profile


Mark E. Hahn

Woods Hole Oceanographic Institution
Biology Dept., MS-32
45 Water Street
Woods Hole, MA 2543


Taxa Studied: Vertebrate Animals, Fundulus heteroclitus, Danio rerio
Techniques Employed: Degenerate PCR, Quantitative PCR (qPCR), Microarrays, Sanger Sequencing, 454 Pyrosequencing, Solexa (Illumina) Sequencing, SOLiD Sequencing, Bioinformatics/Sequence Analysis, SNP Mapping, In Situ Hybridization, Antibody Staining, Sectioning for Histology, Morpholinos, Mutagenesis, ZFN-based gene targeting, microRNA analysis, receptor-ligand-binding assay
Research Description: The overall objective of research in our laboratory is to understand the biochemical and molecular mechanisms that underlie the interactions of animals with their chemical environment. We examine these mechanisms from comparative and evolutionary perspectives in order to understand the fundamental features of the biochemical systems that control the response of animals to toxic chemicals. Our research is guided by general questions such as: • How did chemical signaling pathways evolve in metazoans? • What is the role of these pathways in adaptation to long-term chemical exposure? • What is the mechanistic basis for differential sensitivity to chemicals among species and populations of animals? • What are the mechanisms by which chemicals disrupt embryonic development?
Lab Web Page: http://www.whoi.edu/science/B/people/mhahn/hahn.html
Willing to Host Undergraduates: NO
Actively Seeking Undergraduates: NO
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