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lab profile
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Yoav Soen Weizmann Institute of Science
Rehovot, Israel 76100
Israel
yoavs@weizmann.ac.il
-9345047
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| PI: |
YES |
| Taxa Studied: |
Invertebrate Animals |
| Techniques Employed: |
Quantitative PCR (qPCR), Microarrays, Solexa (Illumina) Sequencing, Antibody Staining, RNA interference(RNAi), Confocal Microscopy, Transgenesis |
| Research Description: |
Our lab is interested in developmental plasticity and gene environment interactions on timescales extending over few generations. As part of this interest, we developed an experimental framework for studying: (1) the ability of developing flies (D. melanogaster) to cope with unfamiliar patterns of toxic stress, (2) the underlying epigenetic mechanisms of response and (3) the trans-generational implications of this stressful condition. We discovered that this stress modifies normal development via suppression of Polycomb function. Remarkably, some of the induced phenotypes persist for several generations of non-exposed offspring. Much of our effort is now directed towards deciphering mechanisms underlying the non-Mendelian inheritance of the response as well as testing whether and how transient inheritance might become more stable. |
| Lab Web Page: |
http://www.weizmann.ac.il/Biological_Chemistry/scientist/Soen/research.html |
| Willing to Host Undergraduates: |
YES |
| Actively Seeking Undergraduates: |
YES |
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