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Yoav Soen

Weizmann Institute of Science
Rehovot, Israel 76100


Taxa Studied: Invertebrate Animals
Techniques Employed: Quantitative PCR (qPCR), Microarrays, Solexa (Illumina) Sequencing, Antibody Staining, RNA interference(RNAi), Confocal Microscopy, Transgenesis
Research Description: Our lab is interested in developmental plasticity and gene environment interactions on timescales extending over few generations. As part of this interest, we developed an experimental framework for studying: (1) the ability of developing flies (D. melanogaster) to cope with unfamiliar patterns of toxic stress, (2) the underlying epigenetic mechanisms of response and (3) the trans-generational implications of this stressful condition. We discovered that this stress modifies normal development via suppression of Polycomb function. Remarkably, some of the induced phenotypes persist for several generations of non-exposed offspring. Much of our effort is now directed towards deciphering mechanisms underlying the non-Mendelian inheritance of the response as well as testing whether and how transient inheritance might become more stable.
Lab Web Page: http://www.weizmann.ac.il/Biological_Chemistry/scientist/Soen/research.html
Willing to Host Undergraduates: YES
Actively Seeking Undergraduates: YES
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